Six Degrees of Separation is the theory that anyone in the world can be connected to another person on the planet through a chain of no more than four people. Welcome to the show that puts this theory to the test. Six Degrees of Separation challenges one lucky candidate to reach a given target person in less than six handshakes within a certain period of time; even if both people are on opposites sides of the world.

Candidates can run, drive, fly and do whatever is necessary to meet their target, in person, as fast as possible.